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MLB Prop Bets: Chicago Cubs vs Miami Marlins (September 22, 2026)

The Miami Marlins (76-80) face the Chicago Cubs (87-69) at Wrigley Field on Tuesday at 7:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Janson Junk is the probable pitcher for the Marlins, while Kevin Gausman is the probable pitcher for the Cubs.

  • The Marlins have an 80-73-3 O/U record this season (meaning 80 games have gone over the total runs line, 73 have gone under and three have resulted in a push). The Cubs have an 86-65-5 O/U record.

Scoring Insights

  • The Marlins are averaging 4.4 runs per game this season (17th in the league). Comparatively, the Cubs are averaging +0.9 more at 5.4 runs (1st).
  • In the field, the Marlins are allowing 4.5 runs per game this season (17th in the league), while the Cubs are allowing an average of 4.4 runs (12th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Marlins are at .249 (ranking 7th in the Major leagues), while the Cubs are batting .252 (6th).

Home Runs

  • In terms of total home runs this season, the Cubs have hit 217 (1st in the Major Leagues). Meanwhile, the Marlins have managed 161 (T23rd).

Runs Batted In

  • Finally, looking at their runs batted in, the Marlins have recorded 662 RBIs to rank T16th in the MLB this season. Comparatively, the Cubs have recorded 790 RBIs to rank 1st.

Pitching Insights:

Earned Run Average

  • The Cubs have an earned run average of 4.16 this season (16th in the Majors), while The Marlins have an ERA of 4.16 (15th).

Strikeouts

  • Turning our attention to total strikeouts, the Marlins have recorded 1265 this season, ranking 19th in the MLB. Meanwhile, the Cubs rank 26th for total strikeouts, recording 1212.

Opponent Batting Average

  • Opponents are batting an average of .243 against the Cubs this season (17th in the Major Leagues). Comparatively, the Marlins' opponents are at .237 (9th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Marlins 28-29-99 15-13-50 13-16-49 14-9-46 14-20-53 0-0-0 0-2-8
    Cubs 37-32-87 25-16-37 12-16-50 32-19-58 5-13-29 0-0-0 3-4-3

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Marlins 59-58-39 35-23-20 24-35-19 29-18-22 30-40-17 0-0-0 4-4-2
    Cubs 64-48-44 41-20-17 23-28-27 54-28-27 10-20-17 0-0-0 7-3-0

NRFI/YRFI

  • The NRFI is 92-64 in Marlins games this season. The Cubs have an 82-74 NRFI record.

Last Time They Met

The Marlins recorded a 10-3 victory over the Cubs at LoanDepot Park when these teams last met on September 6. Heriberto Hernandez was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs. That result snapped the Cubs' four-game winning streak against the Marlins.