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MLB Prop Bets: Los Angeles Dodgers vs San Diego Padres (September 22, 2026)

The San Diego Padres (87-69) face the Los Angeles Dodgers (96-60) at UNIQLO Field at Dodger Stadium on Tuesday at 10:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Michael King is the probable pitcher for the Padres, while Yoshinobu Yamamoto is the probable pitcher for the Dodgers.

  • The Padres have a 72-78-6 O/U record this season (meaning 72 games have gone over the total runs line, 78 have gone under and six have resulted in a push). The Dodgers have a 71-79-6 O/U record.

Scoring Insights

  • The Padres are averaging 4.4 runs per game this season (18th in the league). Comparatively, the Dodgers are averaging +0.6 more at 5.0 runs (4th).
  • In the field, the Padres are allowing 4.2 runs per game this season (9th in the league), while the Dodgers are allowing an average of 3.8 runs (2nd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Padres are at .244 (ranking 17th in the Major leagues), while the Dodgers are batting .257 (3rd).

Home Runs

  • In terms of total home runs this season, the Dodgers have hit 197 (8th in the Major Leagues). Meanwhile, the Padres have managed 179 (T14th).

Runs Batted In

  • Finally, looking at their runs batted in, the Padres have recorded 665 RBIs to rank 15th in the MLB this season. Comparatively, the Dodgers have recorded 736 RBIs to rank 4th.

Pitching Insights:

Earned Run Average

  • The Dodgers have an earned run average of 3.62 this season (5th in the Majors), while The Padres have an ERA of 3.94 (10th).

Strikeouts

  • Turning our attention to total strikeouts, the Padres have recorded 1267 this season, ranking 18th in the MLB. Meanwhile, the Dodgers rank 4th for total strikeouts, recording 1450.

Opponent Batting Average

  • Opponents are batting an average of .219 against the Dodgers this season (1st in the Major Leagues). Comparatively, the Padres' opponents are at .241 (14th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 29-29-98 15-13-50 14-16-46 21-13-48 8-16-50 0-0-2 3-3-4
    Dodgers 40-32-84 26-13-39 14-19-45 40-28-81 0-4-3 0-0-0 4-1-5

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 54-62-40 30-31-17 23-30-23 30-28-24 24-34-16 1-1-0 6-2-2
    Dodgers 71-53-32 35-25-18 36-28-14 71-46-32 0-7-0 0-0-0 5-4-1

NRFI/YRFI

  • The NRFI is 92-64 in Padres games this season. The Dodgers have a 78-78 NRFI record.

Last Time They Met

The Padres recorded an upset 5-2 victory over the Dodgers at UNIQLO Field at Dodger Stadium when these teams last met on July 5. Manny Machado went yard en route to that victory, hitting a home run to go with 3 RBIs. That result snapped the Dodgers' six-game winning streak against the Padres at UNIQLO Field at Dodger Stadium.