MLB Prop Bets: Pittsburgh Pirates vs St. Louis Cardinals (September 22, 2026)
The St. Louis Cardinals (76-80) face the Pittsburgh Pirates (79-77) at PNC Park on Tuesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Andre Pallante is the probable pitcher for the Cardinals, while Jared Jones is the probable pitcher for the Pirates.
- The Cardinals have a 73-77-6 O/U record this season (meaning 73 games have gone over the total runs line, 77 have gone under and six have resulted in a push). The Pirates have an 80-69-7 O/U record.
Scoring Insights
- The Cardinals are averaging 4.5 runs per game this season (12th in the league). Comparatively, the Pirates are averaging 4.8 (5th).
- In the field, the Cardinals are allowing 4.7 runs per game this season (22nd in the league), while the Pirates are allowing an average of 4.6 runs (20th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .242 (ranking 19th in the Major leagues), while the Pirates are batting .254 (4th).
Home Runs
- In terms of total home runs this season, the Pirates have hit 181 (12th in the Major Leagues). Meanwhile, the Cardinals have managed 161 (T23rd).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 681 RBIs to rank T9th in the MLB this season. Comparatively, the Pirates have recorded 715 RBIs to rank 5th.
Pitching Insights:
Earned Run Average
- The Pirates have an earned run average of 4.19 this season (19th in the Majors), while The Cardinals have an ERA of 4.29 (22nd).
Strikeouts
- Turning our attention to total strikeouts, the Cardinals have recorded 1235 this season, ranking 24th in the MLB. Meanwhile, the Pirates rank 5th for total strikeouts, recording 1429.
Opponent Batting Average
- Opponents are batting an average of .238 against the Pirates this season (12th in the Major Leagues). Comparatively, the Cardinals' opponents are at .254 (26th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 33-33-90 | 13-15-53 | 20-18-37 | 13-14-27 | 20-19-63 | 0-0-0 | 1-4-5 |
| Pirates | 41-29-86 | 23-15-40 | 18-14-46 | 25-12-42 | 16-17-44 | 0-0-0 | 2-3-5 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 66-50-40 | 34-25-22 | 32-25-18 | 27-15-12 | 39-35-28 | 0-0-0 | 4-5-1 |
| Pirates | 61-55-40 | 38-21-19 | 23-34-21 | 37-23-19 | 24-32-21 | 0-0-0 | 3-6-1 |
NRFI/YRFI
- The NRFI is 80-76 in Cardinals games this season. The Pirates have an 82-74 NRFI record.
Last Time They Met
The Pirates recorded a 5-4 victory over the Cardinals at Busch Stadium when these teams last met on August 30. Oneil Cruz led the way to that victory, hitting a home run.
