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MLB Prop Bets: Chicago Cubs vs Cincinnati Reds (May 4, 2026)

The Cincinnati Reds (20-14) face the Chicago Cubs (22-12) at Wrigley Field on Monday at 7:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Chase Petty is the probable pitcher for the Reds, while Edward Cabrera is the probable pitcher for the Cubs. The Cubs are favored to win at -219, while the Reds are at +179. The total runs line is set at 11.5, with OVER at -102 and UNDER at -118.

  • The Reds (-105) have a 20-14 Run Line record this season, while the Cubs (-115) hold a record of 18-16.
  • The Reds have a 21-13-0 O/U record this season (meaning 21 games have gone over the total runs line and 13 have gone under). The Cubs have a 21-11-2 O/U record.

Scoring Insights

  • The Reds are averaging 4.1 runs per game this season (23rd in the league). Comparatively, the Cubs are averaging +1.3 more at 5.4 runs (2nd).
  • In the field, the Reds are allowing 4.8 runs per game this season (21st in the league), while the Cubs are allowing an average of 4.2 runs (9th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Cubs are at an impressive .261 (ranking 4th in the Major leagues), while the Reds are batting an underwhelming .217 (30th).

Home Runs

  • In terms of total home runs this season, the Cubs have hit 44 (T4th in the Major Leagues). Meanwhile, the Reds have managed 44 (T4th).

Runs Batted In

  • Finally, looking at their runs batted in, the Cubs have been outstanding this season, recording 169 RBIs to rank T4th in the MLB. Comparatively, the Reds have performed poorly in this area, recording only 130 RBIs to rank 25th.

Pitching Insights:

Earned Run Average

  • The Cubs have an earned run average of 3.89 this season (11th in the Majors), while The Reds have an ERA of 4.50 (21st).

Strikeouts

  • Turning our attention to total strikeouts, the Reds have recorded 268 this season, ranking T24th in the MLB. Meanwhile, the Cubs rank 19th for total strikeouts, recording 278.

Opponent Batting Average

  • Opponents are batting an average of .227 against the Cubs this season (7th in the Major Leagues). Comparatively, the Reds' opponents are at .255 (22nd).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Reds 8-10-16 5-5-8 3-5-8 3-2-4 5-8-12 0-0-0 2-5-3
    Cubs 5-6-23 4-2-13 1-4-10 4-2-16 1-4-7 0-0-0 1-2-7

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Reds 9-15-10 6-8-4 3-7-6 4-3-2 5-12-8 0-0-0 2-7-1
    Cubs 18-8-8 11-3-5 7-5-3 13-3-6 5-5-2 0-0-0 7-2-1

NRFI/YRFI

The NRFI market is paying +125 and the YRFI is paying -160.

  • The NRFI is 15-19 in Reds games this season. The Cubs have a 23-11 NRFI record.

Last Time They Met

The Reds recorded an 1-0 victory over the Cubs at Great American Ball Park when these teams last met on September 21, 2025. Gavin Lux went yard en route to that victory, hitting a home run to go with an RBI. The Reds have now won four straight against the Cubs.