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MLB Prop Bets: St. Louis Cardinals vs Milwaukee Brewers (May 6, 2026)

The Milwaukee Brewers (18-16) face the St. Louis Cardinals (21-14) at Busch Stadium on Wednesday at 1:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Brandon Sproat is the probable pitcher for the Brewers, while Andre Pallante is the probable pitcher for the Cardinals. The Brewers opened as favorites but this has since changed, with the Cardinals coming into -112 and Brewers drifting to -108. The total runs line is set at 8.5, with OVER at -110 and UNDER at -110.

  • The Brewers (+145) have a 19-15 Run Line record this season, while the Cardinals (-176) hold a record of 23-12.
  • The Brewers have a 17-16-1 O/U record this season (meaning 17 games have gone over the total runs line, 16 have gone under and one has resulted in a push). The Cardinals have an 18-16-1 O/U record.

Scoring Insights

  • The Brewers are averaging 5.1 runs per game this season (4th in the league). Comparatively, the Cardinals are averaging 4.9 (9th).
  • In the field, the Brewers are allowing only 3.9 runs per game this season (5th in the league), while the Cardinals are allowing an average of 4.8 runs (23rd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Brewers are at .241 (ranking 16th in the Major leagues), while the Cardinals are batting .242 (14th).

Home Runs

  • In terms of total home runs this season, the Cardinals have hit 44 (9th in the Major Leagues). Meanwhile, the Brewers have managed 23 (29th).

Runs Batted In

  • Finally, looking at their runs batted in, the Brewers have recorded 168 RBIs to rank T8th in the MLB this season. Comparatively, the Cardinals have recorded 168 RBIs to rank T8th.

Pitching Insights:

Earned Run Average

  • The Cardinals have an earned run average of 4.50 this season (22nd in the Majors), while The Brewers have an ERA of 3.64 (4th).

Strikeouts

  • Turning our attention to total strikeouts, the Brewers have recorded 318 this season, ranking 10th in the MLB. Meanwhile, the Cardinals rank 30th for total strikeouts, recording 243.

Opponent Batting Average

  • Opponents are batting an average of .262 against the Cardinals this season (26th in the Major Leagues). Comparatively, the Brewers' opponents are at .234 (9th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Brewers 8-8-18 4-5-9 4-3-9 7-5-11 1-3-7 0-0-0 4-0-6
    Cardinals 6-5-24 2-2-15 4-3-9 0-2-1 6-3-23 0-0-0 2-1-7

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Brewers 13-12-9 7-6-5 6-6-4 10-6-7 3-6-2 0-0-0 5-2-3
    Cardinals 16-10-9 9-4-6 7-6-3 1-1-1 15-9-8 0-0-0 8-2-0

NRFI/YRFI

The NRFI market is paying -125 and the YRFI is paying -105.

  • The NRFI is 18-16 in Brewers games this season. The Cardinals have a 19-16 NRFI record.

Last Time They Met

The Cardinals recorded a 6-3 victory over the Brewers at Busch Stadium on Monday. Brice Turang dominated at the plate in that matchup, notching 1 home run, 2 singles and 2 RBIs.