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MLB Prop Bets: Kansas City Royals vs Cleveland Guardians (May 6, 2026)

The Cleveland Guardians (18-19) face the Kansas City Royals (17-19) at Kauffman Stadium on Wednesday at 7:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Joey Cantillo is the probable pitcher for the Guardians, while Cole Ragans is the probable pitcher for the Royals. The Royals are favored to win at -131, while the Guardians are at +109. The total runs line is set at 8.0, with OVER at -102 and UNDER at -118.

  • The Guardians (-194) have an 18-19 Run Line record this season, while the Royals (+159) hold a record of 19-17.
  • The Guardians have an 18-19-0 O/U record this season (meaning 18 games have gone over the total runs line and 19 have gone under). The Royals have a 15-19-2 O/U record.

Scoring Insights

  • The Guardians are averaging 4.1 runs per game this season (24th in the league). Comparatively, the Royals are averaging 4.2 (21st).
  • In the field, the Guardians are allowing 4.3 runs per game this season (12th in the league), while the Royals are allowing an average of 4.5 runs (17th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Guardians are at .230 (ranking 26th in the Major leagues), while the Royals are batting .241 (17th).

Home Runs

  • In terms of total home runs this season, the Royals have hit 37 (T17th in the Major Leagues). Meanwhile, the Guardians have managed 38 (T14th).

Runs Batted In

  • Finally, looking at their runs batted in, the Guardians have recorded 145 RBIs to rank T20th in the MLB this season. Comparatively, the Royals have recorded 144 RBIs to rank 22nd.

Pitching Insights:

Earned Run Average

  • The Royals have an earned run average of 4.28 this season (18th in the Majors), while The Guardians have an ERA of 4.06 (14th).

Strikeouts

  • Turning our attention to total strikeouts, the Guardians have recorded 334 this season, ranking T2nd in the MLB. Meanwhile, the Royals rank T14th for total strikeouts, recording 304.

Opponent Batting Average

  • Opponents are batting an average of .237 against the Royals this season (12th in the Major Leagues). Comparatively, the Guardians' opponents are at .235 (11th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 7-6-24 3-2-11 4-4-13 3-4-11 4-2-13 0-0-0 0-4-6
    Royals 4-8-24 2-4-12 2-4-12 1-4-12 3-4-12 0-0-0 3-2-5

Lead After Three Innings

The Guardians are +105 to lead after three innings, while the Royals are -135.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 13-12-12 6-4-6 7-8-6 6-4-8 7-8-4 0-0-0 3-4-3
    Royals 11-17-8 7-7-4 4-10-4 4-10-3 7-7-5 0-0-0 3-5-2

NRFI/YRFI

The NRFI market is paying -150 and the YRFI is paying +115.

  • The NRFI is 21-16 in Guardians games this season. The Royals have a 23-13 NRFI record.

Last Time They Met

The Royals recorded a 5-3 victory over the Guardians at Kauffman Stadium yesterday. Isaac Collins was unstoppable in that matchup, hitting a home run, a double and recording an RBI. The Royals have now won three straight at Kauffman Stadium against the Guardians.