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MLB Prop Bets: San Francisco Giants vs San Diego Padres (September 11, 2026)

The San Diego Padres (78-68) face the San Francisco Giants (62-85) at Oracle Park on Friday at 10:15pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Robbie Ray is the probable pitcher for the Padres, while Anthony Molina is the probable pitcher for the Giants. The Padres are favored to win at -143, while the Giants are at +118. The total runs line is set at 8.0, with OVER at -107 and UNDER at -112.

  • The Padres (+118) have a 75-71 Run Line record this season, while the Giants (-142) hold a record of 75-72.
  • The Padres have a 63-78-5 O/U record this season (meaning 63 games have gone over the total runs line, 78 have gone under and five have resulted in a push). The Giants have a 68-66-13 O/U record.

Scoring Insights

  • The Padres are averaging 4.2 runs per game this season (23rd in the league). Comparatively, the Giants are averaging 4.2 (24th).
  • In the field, the Padres are allowing 4.1 runs per game this season (7th in the league), while the Giants are allowing an average of 4.7 runs (23rd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Padres are at .238 (ranking 23rd in the Major leagues), while the Giants are batting .248 (8th).

Home Runs

  • In terms of total home runs this season, the Giants have hit 166 (16th in the Major Leagues). Meanwhile, the Padres have managed 161 (20th).

Runs Batted In

  • Finally, looking at their runs batted in, the Padres have recorded 596 RBIs to rank T23rd in the MLB this season. Comparatively, the Giants have recorded 596 RBIs to rank T23rd.

Pitching Insights:

Earned Run Average

  • The Giants have an earned run average of 4.35 this season (23rd in the Majors), while The Padres have an ERA of 3.88 (9th).

Strikeouts

  • Turning our attention to total strikeouts, the Padres have recorded 1189 this season, ranking 18th in the MLB. Meanwhile, the Giants rank 27th for total strikeouts, recording 1099.

Opponent Batting Average

  • Opponents are batting an average of .247 against the Giants this season (19th in the Major Leagues). Comparatively, the Padres' opponents are at .240 (13th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 26-26-94 15-13-47 11-13-45 18-10-44 8-16-50 0-0-2 3-0-7
    Giants 37-35-75 21-9-42 16-26-33 11-6-29 26-29-46 0-0-0 5-3-2

Lead After Three Innings

The Padres are -140 to lead after three innings, while the Giants are +110.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 48-60-38 29-29-17 18-30-21 24-26-22 24-34-16 1-1-0 3-3-4
    Giants 50-59-38 25-25-22 25-34-16 16-15-15 34-44-23 0-0-0 4-5-1

NRFI/YRFI

The NRFI market is paying -130 and the YRFI is paying +100.

  • The NRFI is 89-57 in Padres games this season. The Giants have a 72-75 NRFI record.

Last Time They Met

The Padres recorded a 5-4 victory over the Giants at Petco Park when these teams last met on August 2. Jackson Merrill was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs. The Padres have now won three straight against the Giants.