MLB Prop Bets: San Francisco Giants vs Minnesota Twins (September 22, 2026)
The Minnesota Twins (73-84) face the San Francisco Giants (65-92) at Oracle Park on Tuesday at 9:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Taj Bradley is the probable pitcher for the Twins, while Anthony Molina is the probable pitcher for the Giants. The Twins are favored to win at -131, while the Giants are at +109. The total runs line is set at 7.5, with OVER at -113 and UNDER at -107.
- The Twins (+130) have an 83-74 Run Line record this season, while the Giants (-157) hold a record of 80-77.
- The Twins have an 84-62-11 O/U record this season (meaning 84 games have gone over the total runs line, 62 have gone under and 11 have resulted in a push). The Giants have a 75-69-13 O/U record.
Scoring Insights
- The Twins are averaging 4.5 runs per game this season (11th in the league). Comparatively, the Giants are averaging only 4.2 (23rd).
- In the field, the Twins are allowing a whopping 5.0 runs per game this season (26th in the league), while the Giants are allowing an average of 4.7 runs (23rd).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Twins are at .244 (ranking 14th in the Major leagues), while the Giants are batting .247 (10th).
Home Runs
- In terms of total home runs this season, the Giants have hit 178 (17th in the Major Leagues). Meanwhile, the Twins have managed 182 (12th).
Runs Batted In
- Finally, looking at their runs batted in, the Twins have recorded 683 RBIs to rank 9th in the MLB this season. Comparatively, the Giants have recorded 638 RBIs to rank 23rd.
Pitching Insights:
Earned Run Average
- The Giants have an earned run average of 4.38 this season (23rd in the Majors), while The Twins have an ERA of 4.60 (25th).
Strikeouts
- Turning our attention to total strikeouts, the Twins have recorded 1338 this season, ranking 12th in the MLB. Meanwhile, the Giants rank 27th for total strikeouts, recording 1167.
Opponent Batting Average
- Opponents are batting an average of .249 against the Giants this season (21st in the Major Leagues). Comparatively, the Twins' opponents are at .249 (22nd).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Twins | 38-44-75 | 19-14-44 | 19-29-31 | 13-13-26 | 25-31-49 | 0-1-0 | 2-4-4 |
| Giants | 42-38-77 | 24-10-42 | 18-28-35 | 11-6-29 | 31-32-48 | 0-0-0 | 5-3-2 |
Lead After Three Innings
The Twins are -135 to lead after three innings, while the Giants are +105.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Twins | 63-65-29 | 34-25-18 | 29-39-11 | 23-18-11 | 40-47-18 | 0-1-0 | 5-5-0 |
| Giants | 55-62-40 | 26-27-23 | 29-35-17 | 16-15-15 | 39-47-25 | 0-0-0 | 5-3-2 |
NRFI/YRFI
The NRFI market is paying -130 and the YRFI is paying +100.
- The NRFI is 63-94 in Twins games this season. The Giants have a 74-83 NRFI record.
Last Time They Met
The Giants recorded a 5-2 victory over the Twins at Oracle Park yesterday. Drew Gilbert dominated at the plate in that matchup, notching 1 home run, 2 singles and 3 RBIs. That result snapped the Twins' three-game winning streak against the Giants.
