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NFL Prop Bets: San Francisco 49ers vs Arizona Cardinals - Week 3

The Arizona Cardinals (1-1) face the San Francisco 49ers (2-0) at Levi's Stadium for Week 3. Let's take a look at the NFL Prop Bets for Sunday's matchup. The 49ers are favored to win at -455, currently marked as 8.5-point favorites, while the Cardinals are at +350.

The total points line is set at 47.5, with OVER at -115 and UNDER at -105, meaning the implied expected score for the game is 28-20 San Francisco.

  • The Cardinals (-115) have a 7-12-0 ATS record since the beginning of last season, while the 49ers (-105) hold a record of 12-7-2 across the same span.
  • The Cardinals have a 10-9-0 O/U record since the beginning of last season (meaning 10 games have gone over the total points line and nine have gone under). The 49ers have a 12-8-1 O/U record over the same span.

Points on the board

  • The Cardinals have scored 20.4 points per game since the beginning of last season (24th in the league). Comparatively, the 49ers are performing better over the same span, averaging 26.3 (10th).
  • Defensively, the Cardinals have conceded a whopping 28.1 points per game since the beginning of last season (T30th in the league), while the 49ers have given up an average of 20.6 points over that span (10th).

Moving the chains

  • With an average of just 320.1, the Cardinals rank 22nd in the league for total yards per game since the beginning of last season. Comparatively, the 49ers rank 7th with 354.5 yards per game over the same span.
  • In terms of yards allowed, the Cardinals have given up 354.2 per game since the beginning of last season (26th in the league), while the 49ers have allowed an average of 334.6 (18th).

Ascendency in the air

  • The Cardinals have recorded 227.0 passing yards per game since the beginning of last season (8th in the league). Comparatively, the 49ers' defense has given up 226.4 passing yards per game (21st) across the same period.
  • Meanwhile, the 49ers have recorded 244.7 passing yards per game since the beginning of last season (4th in the league), which will put fear into the heart of a Cardinals defense which is conceding 227.8 passing yards per game (23rd) over the same period.

Advantage on the ground

  • Looking at the ground game, the Cardinals have recorded 93.1 rushing yards per game since the beginning of last season (30th in the league). Conversely, the 49ers are giving up 108.3 rushing yards per game (10th) across the same period.
  • On the other hand, the 49ers have recorded 109.8 rushing yards per game since the beginning of last season (23rd in the league). The Cardinals have performed at a poor level when defending the run, conceding 126.4 per game (23rd).

Protecting the ball

  • Looking at their ability to force turnovers, the Cardinals have recorded 22 total takeaways since the beginning of last season (T13th in the league), while the 49ers have failed to perform at the same level, recording 18 (T24th).
  • On offense, the Cardinals have recorded 22 total giveaways since the beginning of last season (T16th in the league), while the 49ers have recorded 23 (T18th).

First to Score

The Cardinals are +150 to score first, while the 49ers are -195.

  • The Cardinals have scored first in 10 of their 19 games since the beginning of last season.
  • The 49ers have scored first in 11 of their 21 games since the beginning of last season.

Which team will score the first touchdown?

The Cardinals are +180 to record the first touchdown, while the 49ers are -225.

  • The Cardinals have recorded the first touchdown in seven of their 19 games since the beginning of last season.
  • The 49ers have recorded the first touchdown in 11 of their 19 games since the beginning of last season.

First Scoring Play

    Play Frequency Odds
    Arizona Touchdown4 / 19+353
    Arizona Field Goal6 / 19+444
    Arizona Safety0 / 19+7200
    San Francisco Touchdown9 / 19+123
    San Francisco Field Goal2 / 19+350
    San Francisco Safety0 / 19+6600

Which team will get a quick start?

The Cardinals are +211 to be the first team to reach 10 points, while the 49ers are -271.

  • The Cardinals have been the first to score 10 points in seven of their 19 games since the beginning of last season.
  • The 49ers have been the first to score 10 points in 14 of their 19 games since the beginning of last season.

First Quarter Moneyline

The 49ers are favored in the 1st Quarter Moneyline market, currently at -258, while the Cardinals are +210.

  • The Cardinals have a 6-7-6 first quarter W/L/T record since the beginning of last season, while the 49ers hold a record of 12-5-4 across the same span.

Last Time They Met

The 49ers recorded a 41-22 victory over the Cardinals at State Farm Stadium when these teams last met in Week 11, 2025.