MLB Prop Bets: San Francisco Giants vs Arizona Diamondbacks (September 10, 2025)
The Arizona Diamondbacks (72-74) face the San Francisco Giants (74-71) at Oracle Park on Wednesday at 3:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Eduardo Rodriguez is the probable pitcher for the Diamondbacks, while Carson Seymour is the probable pitcher for the Giants. The Giants are favored to win at -115, while the Diamondbacks are at -106. The total runs line is set at 8.0, with OVER at -118 and UNDER at -104.
- The Diamondbacks (+156) have a 72-74 Run Line record this season, while the Giants (-195) hold a record of 67-78.
- The Diamondbacks have a 70-67-9 O/U record this season (meaning 70 games have gone over the total runs line, 67 have gone under and nine have resulted in a push). The Giants have a 69-70-6 O/U record.
Scoring Insights
- The Diamondbacks are averaging 4.9 runs per game this season (6th in the league). Comparatively, the Giants are averaging 4.4 (15th).
- In the field, the Diamondbacks are allowing 4.8 runs per game this season (23rd in the league), while the Giants are allowing an average of 4.1 runs (10th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Diamondbacks are at .250 (ranking 11th in the Major leagues), while the Giants are batting .239 (24th).
Home Runs
- In terms of total home runs this season, the Giants have hit 159 (19th in the Major Leagues). Meanwhile, the Diamondbacks have managed 198 (T6th).
Runs Batted In
- Finally, looking at their runs batted in, the Diamondbacks have recorded 700 RBIs to rank 2nd in the MLB this season. Comparatively, the Giants have recorded 605 RBIs to rank 16th.
Pitching Insights:
Earned Run Average
- The Giants have an earned run average of 3.75 this season (6th in the Majors), while The Diamondbacks have an ERA of 4.48 (23rd).
Strikeouts
- Turning our attention to total strikeouts, the Diamondbacks have recorded 1156 this season, ranking 21st in the MLB. Meanwhile, the Giants rank 13th for total strikeouts, recording 1226.
Opponent Batting Average
- Opponents are batting an average of .246 against the Giants this season (20th in the Major Leagues). Comparatively, the Diamondbacks' opponents are at .253 (24th).
First Innings Moneyline
- Here are their first innings moneyline records in 2025.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Diamondbacks | 42-37-67 | 28-13-31 | 14-24-36 | 29-16-37 | 13-21-30 | 0-0-0 | 3-2-5 |
| Giants | 36-32-77 | 16-13-42 | 20-19-35 | 22-19-47 | 14-13-30 | 0-0-0 | 6-0-4 |
Lead After Three Innings
The Diamondbacks are -106 to lead after three innings, while the Giants are -125.
- Here are their records after the first three innings in 2025.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Diamondbacks | 64-55-27 | 38-24-10 | 26-31-17 | 43-28-11 | 21-27-16 | 0-0-0 | 5-3-2 |
| Giants | 57-53-35 | 23-29-19 | 34-24-16 | 32-32-24 | 25-21-11 | 0-0-0 | 6-1-3 |
NRFI/YRFI
The NRFI market is paying -115 and the YRFI is paying -115.
- The NRFI is 64-82 in Diamondbacks games this season. The Giants have a 71-74 NRFI record.
Last Time They Met
The Giants recorded a 5-3 victory over the Diamondbacks at Oracle Park yesterday. Willy Adames went yard en route to that victory, hitting a home run to go with 3 RBIs. The Giants have now won four straight against the Diamondbacks.
