MLB Prop Bets: Seattle Mariners vs St. Louis Cardinals (September 10, 2025)
The St. Louis Cardinals (72-74) face the Seattle Mariners (77-68) at T-Mobile Park on Wednesday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Michael McGreevy is the probable pitcher for the Cardinals, while Logan Gilbert is the probable pitcher for the Mariners. The Mariners are favored to win at -235, while the Cardinals are at +186. The total runs line is set at 7.5, with OVER at -108 and UNDER at -113.
- The Cardinals (-114) have a 71-75 Run Line record this season, while the Mariners (-108) hold a record of 59-86.
- The Cardinals have a 73-65-8 O/U record this season (meaning 73 games have gone over the total runs line, 65 have gone under and eight have resulted in a push). The Mariners have a 79-60-6 O/U record.
Scoring Insights
- The Cardinals are averaging 4.3 runs per game this season (21st in the league). Comparatively, the Mariners are averaging +0.4 more at 4.7 runs (11th).
- In the field, the Cardinals are allowing 4.6 runs per game this season (20th in the league), while the Mariners are allowing an average of 4.4 runs (18th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .245 (ranking 17th in the Major leagues), while the Mariners are batting .243 (20th).
Home Runs
- In terms of total home runs this season, the Mariners are one of the best in the Major Leagues, hitting 212 to rank 3rd. Alternatively, the Cardinals are at the opposite end of the home run standings, hitting just 137 (28th).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 597 RBIs to rank T20th in the MLB this season. Comparatively, the Mariners have recorded 650 RBIs to rank 11th.
Pitching Insights:
Earned Run Average
- The Mariners have an earned run average of 3.99 this season (17th in the Majors), while The Cardinals have an ERA of 4.28 (21st).
Strikeouts
- Turning our attention to total strikeouts, the Cardinals have recorded 1075 this season, ranking 29th in the MLB. Meanwhile, the Mariners rank 11th for total strikeouts, recording 1239.
Opponent Batting Average
- Opponents are batting an average of .245 against the Mariners this season (18th in the Major Leagues). Comparatively, the Cardinals' opponents are at .259 (25th).
First Innings Moneyline
- Here are their first innings moneyline records in 2025.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 24-48-74 | 9-28-38 | 15-20-36 | 10-22-31 | 14-26-43 | 0-0-0 | 1-2-7 |
| Mariners | 31-33-81 | 13-13-44 | 18-20-36 | 23-22-58 | 8-11-23 | 0-0-1 | 1-3-6 |
Lead After Three Innings
The Cardinals are +160 to lead after three innings, while the Mariners are -210.
- Here are their records after the first three innings in 2025.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 49-55-42 | 25-25-25 | 24-30-17 | 26-25-12 | 23-30-30 | 0-0-0 | 1-4-5 |
| Mariners | 55-49-41 | 29-17-24 | 26-31-17 | 42-30-31 | 13-19-10 | 0-1-0 | 3-5-2 |
NRFI/YRFI
The NRFI market is paying -121 and the YRFI is paying -110.
- The NRFI is 73-73 in Cardinals games this season. The Mariners have a 74-71 NRFI record.
Last Time They Met
The Mariners recorded an upset 5-3 victory over the Cardinals at T-Mobile Park yesterday. Josh Naylor dominated at the plate in that matchup, notching 1 home run, 2 singles and an RBI. The Mariners have now won three straight against the Cardinals.
