MLB Prop Bets: Cleveland Guardians vs Houston Astros (April 22, 2026)
The Houston Astros (9-16) face the Cleveland Guardians (14-11) at Progressive Field on Wednesday at 1:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Peter Lambert is the probable pitcher for the Astros, while Tanner Bibee is the probable pitcher for the Guardians. The Guardians are favored to win at -143, while the Astros are at +119. The total runs line is set at 8.0, with OVER at -105 and UNDER at -115.
- The Astros (-181) have a 9-16 Run Line record this season, while the Guardians (+149) hold a record of 14-11.
- The Astros have an 18-7-0 O/U record this season (meaning 18 games have gone over the total runs line and seven have gone under). The Guardians have a 13-12-0 O/U record.
Scoring Insights
- The Astros are averaging 5.4 runs per game this season (4th in the league). Comparatively, the Guardians are averaging only 4.2 (20th).
- In the field, the Astros are allowing a whopping 6.0 runs per game this season (29th in the league), while the Guardians are allowing an average of 4.4 runs (13th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Astros are at .262 (ranking 3rd in the Major leagues), while the Guardians are batting .231 (18th).
Home Runs
- In terms of total home runs this season, the Guardians have hit 26 (T11th in the Major Leagues). Meanwhile, the Astros have managed 30 (5th).
Runs Batted In
- Finally, looking at their runs batted in, the Astros have recorded 127 RBIs to rank 3rd in the MLB this season. Comparatively, the Guardians have recorded 100 RBIs to rank T15th.
Pitching Insights:
Earned Run Average
- The Guardians have an earned run average of 4.08 this season (17th in the Majors), while The Astros have an ERA of 6.05 (30th).
Strikeouts
- Turning our attention to total strikeouts, the Astros have recorded 235 this season, ranking 2nd in the MLB. Meanwhile, the Guardians rank 1st for total strikeouts, recording 238.
Opponent Batting Average
- Opponents are batting an average of .231 against the Guardians this season (10th in the Major Leagues). Comparatively, the Astros' opponents are at .265 (27th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Astros | 8-9-8 | 5-3-5 | 3-6-3 | 4-4-8 | 4-5-0 | 0-0-0 | 3-6-1 |
| Guardians | 6-1-18 | 3-1-8 | 3-0-10 | 2-1-7 | 4-0-11 | 0-0-0 | 3-1-6 |
Lead After Three Innings
The Astros are +105 to lead after three innings, while the Guardians are -135.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Astros | 9-9-7 | 6-4-3 | 3-5-4 | 6-6-4 | 3-3-3 | 0-0-0 | 4-5-1 |
| Guardians | 9-7-9 | 5-3-4 | 4-4-5 | 4-1-5 | 5-6-4 | 0-0-0 | 3-1-6 |
NRFI/YRFI
The NRFI market is paying -125 and the YRFI is paying -105.
- The NRFI is 7-18 in Astros games this season. The Guardians have a 15-10 NRFI record.
Last Time They Met
The Guardians recorded an upset 8-5 victory over the Astros at Progressive Field yesterday. Angel Martinez was unstoppable in that matchup, hitting a home run, a single and recording an RBI.
