MLB Prop Bets: San Francisco Giants vs Los Angeles Dodgers (April 22, 2026)
The Los Angeles Dodgers (16-7) face the San Francisco Giants (10-13) at Oracle Park on Wednesday at 9:45pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Shohei Ohtani is the probable pitcher for the Dodgers, while Tyler Mahle is the probable pitcher for the Giants. The Dodgers are favored to win at -207, while the Giants are at +169. The total runs line is set at 7.5, with OVER at -115 and UNDER at -105.
- The Dodgers (-118) have a 12-11 Run Line record this season, while the Giants (-102) hold a record of 10-13.
- The Dodgers have a 10-12-1 O/U record this season (meaning 10 games have gone over the total runs line, 12 have gone under and one has resulted in a push). The Giants have a 10-11-2 O/U record.
Scoring Insights
- The Dodgers are averaging 5.8 runs per game this season (1st in the league). Comparatively, the Giants are averaging only 3.4 (29th).
- In the field, the Dodgers are allowing only 3.4 runs per game this season (T2nd in the league), while the Giants are allowing an average of 4.2 runs (12th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Dodgers are at .286 (ranking 1st in the Major leagues), while the Giants are batting .250 (T9th).
Home Runs
- In terms of total home runs this season, the Dodgers are one of the best in the Major Leagues, hitting 42 to rank 1st. Alternatively, the Giants are at the opposite end of the home run standings, hitting just 13 (T29th).
Runs Batted In
- Finally, looking at their runs batted in, the Dodgers have been outstanding this season, recording 129 RBIs to rank 2nd in the MLB. Comparatively, the Giants have performed poorly in this area, recording only 74 RBIs to rank 29th.
Pitching Insights:
Earned Run Average
- The Giants have an earned run average of 4.01 this season (T13th in the Majors), while The Dodgers have an ERA of 3.41 (6th).
Strikeouts
- Turning our attention to total strikeouts, the Dodgers have recorded 191 this season, ranking T19th in the MLB. Meanwhile, the Giants rank 12th for total strikeouts, recording 207.
Opponent Batting Average
- Opponents are batting an average of .232 against the Giants this season (11th in the Major Leagues). Comparatively, the Dodgers' opponents are at .211 (2nd).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Dodgers | 7-4-12 | 3-1-8 | 4-3-4 | 7-4-12 | 0-0-0 | 0-0-0 | 5-2-3 |
| Giants | 4-5-14 | 3-1-7 | 1-4-7 | 1-2-5 | 3-3-9 | 0-0-0 | 1-3-6 |
Lead After Three Innings
The Dodgers are -180 to lead after three innings, while the Giants are +140.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Dodgers | 12-8-3 | 4-5-3 | 8-3-0 | 12-8-3 | 0-0-0 | 0-0-0 | 7-2-1 |
| Giants | 8-11-4 | 4-5-2 | 4-6-2 | 2-5-1 | 6-6-3 | 0-0-0 | 3-5-2 |
NRFI/YRFI
The NRFI market is paying -155 and the YRFI is paying +120.
- The NRFI is 11-12 in Dodgers games this season. The Giants have a 14-9 NRFI record.
Last Time They Met
The Giants recorded a 3-1 victory over the Dodgers at Oracle Park yesterday. Despite being on the wrong side of that result, Teoscar Hernandez did what he could, hitting a home run.
