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MLB Prop Bets: Detroit Tigers vs Milwaukee Brewers (April 22, 2026)

The Milwaukee Brewers (13-9) face the Detroit Tigers (12-12) at Comerica Park on Wednesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Chad Patrick is the probable pitcher for the Brewers, while Casey Mize is the probable pitcher for the Tigers. The Tigers are favored to win at -136, while the Brewers are at +113. The total runs line is set at 8.0, with OVER at -102 and UNDER at -118.

  • The Brewers (-194) have a 13-9 Run Line record this season, while the Tigers (+159) hold a record of 11-13.
  • The Brewers have a 13-9-0 O/U record this season (meaning 13 games have gone over the total runs line and nine have gone under). The Tigers have an 11-12-1 O/U record.

Scoring Insights

  • The Brewers are averaging 5.4 runs per game this season (6th in the league). Comparatively, the Tigers are averaging 4.3 (15th).
  • In the field, the Brewers are allowing 4.1 runs per game this season (11th in the league), while the Tigers are allowing an average of 4.0 runs (9th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Brewers are at .241 (ranking 13th in the Major leagues), while the Tigers are batting .246 (11th).

Home Runs

  • In terms of total home runs this season, the Tigers have hit 17 (T25th in the Major Leagues). Meanwhile, the Brewers have managed 19 (T21st).

Runs Batted In

  • Finally, looking at their runs batted in, the Brewers have recorded 113 RBIs to rank 6th in the MLB this season. Comparatively, the Tigers have recorded 99 RBIs to rank T17th.

Pitching Insights:

Earned Run Average

  • The Tigers have an earned run average of 3.70 this season (10th in the Majors), while The Brewers have an ERA of 3.86 (11th).

Strikeouts

  • Turning our attention to total strikeouts, the Brewers have recorded 198 this season, ranking 16th in the MLB. Meanwhile, the Tigers rank 21st for total strikeouts, recording 188.

Opponent Batting Average

  • Opponents are batting an average of .235 against the Tigers this season (15th in the Major Leagues). Comparatively, the Brewers' opponents are at .242 (18th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Brewers 4-7-11 2-5-5 2-2-6 3-5-6 1-2-5 0-0-0 1-2-7
    Tigers 5-3-16 3-0-7 2-3-9 5-2-9 0-1-7 0-0-0 3-0-7

Lead After Three Innings

The Brewers are +114 to lead after three innings, while the Tigers are -145.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Brewers 7-9-6 4-5-3 3-4-3 5-5-4 2-4-2 0-0-0 3-4-3
    Tigers 10-8-6 7-2-1 3-6-5 9-4-3 1-4-3 0-0-0 5-3-2

NRFI/YRFI

The NRFI market is paying -145 and the YRFI is paying +110.

  • The NRFI is 11-11 in Brewers games this season. The Tigers have a 15-9 NRFI record.

Last Time They Met

The Brewers recorded a lopsided 12-4 victory against the Tigers at Comerica Park yesterday. Garrett Mitchell went yard en route to that victory, hitting a home run to go with an RBI. The Brewers have now won three straight against the Tigers.