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MLB Prop Bets: Colorado Rockies vs San Diego Padres (April 22, 2026)

The San Diego Padres (16-7) face the Colorado Rockies (9-15) at Coors Field on Wednesday at 8:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Walker Buehler is the probable pitcher for the Padres, while Tomoyuki Sugano is the probable pitcher for the Rockies. The Padres are favored to win at -163, while the Rockies are at +135. The total runs line is set at 12.0, with OVER at -106 and UNDER at -114.

  • The Padres (-108) have a 13-10 Run Line record this season, while the Rockies (-112) hold a record of 15-9.
  • The Padres have a 9-13-1 O/U record this season (meaning nine games have gone over the total runs line, 13 have gone under and one has resulted in a push). The Rockies have a 9-15-0 O/U record.

Scoring Insights

  • The Padres are averaging 4.2 runs per game this season (T18th in the league). Comparatively, the Rockies are averaging 3.8 (26th).
  • In the field, the Padres are allowing only 3.4 runs per game this season (T2nd in the league), while the Rockies are allowing an average of 4.7 runs (20th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Padres are at .230 (ranking 19th in the Major leagues), while the Rockies are batting .238 (16th).

Home Runs

  • In terms of total home runs this season, the Rockies have hit 23 (19th in the Major Leagues). Meanwhile, the Padres have managed 17 (T25th).

Runs Batted In

  • Finally, looking at their runs batted in, the Padres have recorded 92 RBIs to rank T20th in the MLB this season. Comparatively, the Rockies have recorded 89 RBIs to rank 23rd.

Pitching Insights:

Earned Run Average

  • The Rockies have an earned run average of 4.26 this season (19th in the Majors), while The Padres have an ERA of 3.22 (2nd).

Strikeouts

  • Turning our attention to total strikeouts, the Padres have recorded 220 this season, ranking 6th in the MLB. Meanwhile, the Rockies rank T24th for total strikeouts, recording 185.

Opponent Batting Average

  • Opponents are batting an average of .266 against the Rockies this season (28th in the Major Leagues). Comparatively, the Padres' opponents are at .226 (8th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 2-3-18 2-3-8 0-0-10 2-1-10 0-2-8 0-0-0 1-1-8
    Rockies 6-8-10 3-5-3 3-3-7 0-0-0 6-8-10 0-0-0 3-5-2

Lead After Three Innings

The Padres are -125 to lead after three innings, while the Rockies are -105.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Padres 6-8-9 5-5-3 1-3-6 3-3-7 3-5-2 0-0-0 3-3-4
    Rockies 4-12-8 2-6-3 2-6-5 0-0-0 4-12-8 0-0-0 1-8-1

NRFI/YRFI

The NRFI market is paying +120 and the YRFI is paying -155.

  • The NRFI is 18-5 in Padres games this season. The Rockies have a 10-14 NRFI record.

Last Time They Met

The Padres recorded an 1-0 victory over the Rockies at Coors Field yesterday. Jake Cronenworth led the way to that victory, hitting a home run. The Padres have now won seven straight against the Rockies.