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MLB Prop Bets: Boston Red Sox vs Chicago Cubs Game 2 (September 25, 2026)

The Chicago Cubs (88-71) face the Boston Red Sox (85-74) at Fenway Park on Friday at 6:05pm (ET). Let's take a look at the MLB Prop Bets for the matchup. David Peterson is the probable pitcher for the Cubs, while Brayan Bello is the probable pitcher for the Red Sox. The Cubs are favored to win at -118, while the Red Sox are at -102. The total runs line is set at 6.5, with OVER at -112 and UNDER at -107.

  • The Cubs (+153) have a 78-81 Run Line record this season, while the Red Sox (-186) hold a record of 74-85.
  • The Cubs have an 87-67-5 O/U record this season (meaning 87 games have gone over the total runs line, 67 have gone under and five have resulted in a push). The Red Sox have a 70-85-4 O/U record.

Scoring Insights

  • The Cubs are averaging 5.3 runs per game this season (1st in the league). Comparatively, the Red Sox are averaging only 4.3 (22nd).
  • In the field, the Cubs are allowing 4.4 runs per game this season (12th in the league), while the Red Sox are allowing an average of 3.8 runs (3rd).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Cubs are at .251 (ranking 6th in the Major leagues), while the Red Sox are batting .246 (15th).

Home Runs

  • In terms of total home runs this season, the Red Sox have hit 162 (T24th in the Major Leagues). Meanwhile, the Cubs have managed 218 (T2nd).

Runs Batted In

  • Finally, looking at their runs batted in, the Cubs have recorded 795 RBIs to rank 1st in the MLB this season. Comparatively, the Red Sox have recorded 651 RBIs to rank 22nd.

Pitching Insights:

Earned Run Average

  • The Red Sox have an earned run average of 3.55 this season (3rd in the Majors), while The Cubs have an ERA of 4.15 (17th).

Strikeouts

  • Turning our attention to total strikeouts, the Cubs have recorded 1239 this season, ranking 26th in the MLB. Meanwhile, the Red Sox rank 11th for total strikeouts, recording 1378.

Opponent Batting Average

  • Opponents are batting an average of .241 against the Red Sox this season (14th in the Major Leagues). Comparatively, the Cubs' opponents are at .243 (17th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 37-32-90 25-16-40 12-16-50 32-19-61 5-13-29 0-0-0 2-2-6
    Red Sox 32-43-84 18-18-42 14-25-42 23-28-60 9-15-24 0-0-0 1-2-7

Lead After Three Innings

The Cubs are -130 to lead after three innings, while the Red Sox are +100.

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Cubs 64-49-46 41-21-19 23-28-27 54-29-29 10-20-17 0-0-0 5-3-2
    Red Sox 65-61-33 36-29-13 29-32-20 49-39-23 16-22-10 0-0-0 4-5-1

NRFI/YRFI

The NRFI market is paying -180 and the YRFI is paying +135.

  • The NRFI is 85-74 in Cubs games this season. The Red Sox have a 78-81 NRFI record.

Last Time They Met

The Red Sox recorded a 4-3 victory over the Cubs at Fenway Park earlier today. Roman Anthony led the way to that victory, hitting a home run. The Red Sox have now won three straight at Fenway Park against the Cubs.