MLB Prop Bets: Milwaukee Brewers vs St. Louis Cardinals (September 25, 2026)
The St. Louis Cardinals (77-82) face the Milwaukee Brewers (100-59) at American Family Field on Friday at 7:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Michael McGreevy is the probable pitcher for the Cardinals, while Robert Gasser is the probable pitcher for the Brewers. The Brewers are favored to win at -184, while the Cardinals are at +151. The total runs line is set at 8.0, with OVER at -115 and UNDER at -105.
- The Cardinals (-143) have an 86-73 Run Line record this season, while the Brewers (+119) hold a record of 83-76.
- The Cardinals have a 73-80-6 O/U record this season (meaning 73 games have gone over the total runs line, 80 have gone under and six have resulted in a push). The Brewers have a 71-83-5 O/U record.
Scoring Insights
- The Cardinals are averaging 4.5 runs per game this season (13th in the league). Comparatively, the Brewers are averaging +0.7 more at 5.1 runs (2nd).
- In the field, the Cardinals are allowing 4.6 runs per game this season (T21st in the league), while the Brewers are allowing an average of 3.8 runs (4th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .241 (ranking 20th in the Major leagues), while the Brewers are batting .258 (2nd).
Home Runs
- In terms of total home runs this season, the Brewers have hit 152 (28th in the Major Leagues). Meanwhile, the Cardinals have managed 162 (T24th).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 686 RBIs to rank T11th in the MLB this season. Comparatively, the Brewers have recorded 771 RBIs to rank 2nd.
Pitching Insights:
Earned Run Average
- The Brewers have an earned run average of 3.52 this season (2nd in the Majors), while The Cardinals have an ERA of 4.24 (20th).
Strikeouts
- Turning our attention to total strikeouts, the Cardinals have recorded 1256 this season, ranking 24th in the MLB. Meanwhile, the Brewers rank 3rd for total strikeouts, recording 1509.
Opponent Batting Average
- Opponents are batting an average of only .223 against the Brewers this season (2nd in the Major Leagues). Alternatively, the Cardinals' opponents are at .253 (25th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 33-33-93 | 13-15-53 | 20-18-40 | 13-14-27 | 20-19-66 | 0-0-0 | 1-3-6 |
| Brewers | 41-31-87 | 28-14-35 | 13-17-51 | 37-24-65 | 4-7-22 | 0-0-1 | 1-0-9 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 67-50-42 | 34-25-22 | 33-25-20 | 27-15-12 | 40-35-30 | 0-0-0 | 2-5-3 |
| Brewers | 70-52-37 | 38-19-20 | 32-33-16 | 56-40-30 | 14-12-7 | 0-0-1 | 6-2-2 |
NRFI/YRFI
The NRFI market is paying -125 and the YRFI is paying -105.
- The NRFI is 82-77 in Cardinals games this season. The Brewers have an 83-76 NRFI record.
Last Time They Met
The Brewers recorded an 8-4 victory over the Cardinals at Busch Stadium when these teams last met on July 9. Brice Turang was unstoppable in that matchup, hitting a home run, a single and recording 2 RBIs.
