MLB Prop Bets: San Diego Padres vs Arizona Diamondbacks (September 25, 2026)
The Arizona Diamondbacks (85-74) face the San Diego Padres (89-70) at Petco Park on Friday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Brandon Pfaadt is the probable pitcher for the Diamondbacks, while Casey Mize is the probable pitcher for the Padres. The Padres are favored to win at -142, while the Diamondbacks are at +118. The total runs line is set at 7.0, with OVER at -119 and UNDER at -101.
- The Diamondbacks (-193) have an 88-71 Run Line record this season, while the Padres (+159) hold a record of 83-76.
- The Diamondbacks have a 66-84-9 O/U record this season (meaning 66 games have gone over the total runs line, 84 have gone under and nine have resulted in a push). The Padres have a 72-81-6 O/U record.
Scoring Insights
- The Diamondbacks are averaging 4.5 runs per game this season (12th in the league). Comparatively, the Padres are averaging 4.4 (19th).
- In the field, the Diamondbacks are allowing 4.4 runs per game this season (15th in the league), while the Padres are allowing an average of 4.1 runs (9th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Diamondbacks are at .246 (ranking 14th in the Major leagues), while the Padres are batting .243 (17th).
Home Runs
- In terms of total home runs this season, the Padres have hit 180 (T14th in the Major Leagues). Meanwhile, the Diamondbacks have managed 162 (T24th).
Runs Batted In
- Finally, looking at their runs batted in, the Diamondbacks have recorded 686 RBIs to rank T11th in the MLB this season. Comparatively, the Padres have recorded 673 RBIs to rank 18th.
Pitching Insights:
Earned Run Average
- The Padres have an earned run average of 3.93 this season (10th in the Majors), while The Diamondbacks have an ERA of 4.10 (13th).
Strikeouts
- Turning our attention to total strikeouts, the Diamondbacks have recorded 1118 this season, ranking 29th in the MLB. Meanwhile, the Padres rank 20th for total strikeouts, recording 1295.
Opponent Batting Average
- Opponents are batting an average of .241 against the Padres this season (15th in the Major Leagues). Comparatively, the Diamondbacks' opponents are at .248 (20th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Diamondbacks | 35-42-82 | 20-17-42 | 15-25-38 | 22-15-34 | 13-27-48 | 0-0-2 | 5-2-3 |
| Padres | 29-29-101 | 15-13-50 | 14-16-49 | 21-13-48 | 8-16-53 | 0-0-2 | 2-1-7 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Diamondbacks | 49-73-37 | 29-29-21 | 19-43-16 | 30-24-17 | 19-49-20 | 1-1-0 | 4-4-2 |
| Padres | 54-63-42 | 30-31-17 | 23-31-25 | 30-28-24 | 24-35-18 | 1-1-0 | 4-3-3 |
NRFI/YRFI
The NRFI market is paying -145 and the YRFI is paying +110.
- The NRFI is 73-86 in Diamondbacks games this season. The Padres have a 95-64 NRFI record.
Last Time They Met
The Padres recorded a 5-1 victory over the Diamondbacks at Chase Field when these teams last met on August 6. Despite being on the wrong side of that result, Gabriel Moreno did what he could, hitting a home run.
