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MLB Prop Bets: Kansas City Royals vs Cleveland Guardians (September 25, 2026)

The Cleveland Guardians (83-76) face the Kansas City Royals (68-91) at Kauffman Stadium on Friday at 7:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Gavin Williams is the probable pitcher for the Guardians, while Noah Cameron is the probable pitcher for the Royals. The Guardians are favored to win at -142, while the Royals are at +118. The total runs line is set at 7.5, with OVER at -114 and UNDER at -105.

  • The Guardians (+123) have a 74-85 Run Line record this season, while the Royals (-149) hold a record of 79-80.
  • The Guardians have a 75-82-2 O/U record this season (meaning 75 games have gone over the total runs line, 82 have gone under and two have resulted in a push). The Royals have a 71-82-6 O/U record.

Scoring Insights

  • The Guardians are averaging 4.1 runs per game this season (27th in the league). Comparatively, the Royals are averaging 4.2 (23rd).
  • In the field, the Guardians are allowing 4.1 runs per game this season (8th in the league), while the Royals are allowing an average of 4.9 runs (T25th).

Let's take a look at how these teams perform in some other key statistical areas.

Batting Insights:

Batting Average

  • Looking at their batting averages this season, the Guardians are at .237 (ranking 24th in the Major leagues), while the Royals are batting .246 (12th).

Home Runs

  • In terms of total home runs this season, the Royals have hit 165 (T21st in the Major Leagues). Meanwhile, the Guardians have managed 153 (27th).

Runs Batted In

  • Finally, looking at their runs batted in, the Guardians have recorded 625 RBIs to rank T26th in the MLB this season. Comparatively, the Royals have recorded 640 RBIs to rank 24th.

Pitching Insights:

Earned Run Average

  • The Royals have an earned run average of 4.73 this season (27th in the Majors), while The Guardians have an ERA of 3.73 (8th).

Strikeouts

  • Turning our attention to total strikeouts, the Guardians have recorded an impressive 1510 this season, ranking 2nd in the MLB. Contrastingly, the Royals rank 28th for total strikeouts, recording only 1161.

Opponent Batting Average

  • Opponents are batting an average of .260 against the Royals this season (28th in the Major Leagues). Comparatively, the Guardians' opponents are at .236 (8th).

First Innings Moneyline

  • Here are their first innings moneyline records in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 36-27-96 21-14-46 15-13-50 25-18-57 11-9-39 0-0-0 3-1-6
    Royals 37-39-83 20-21-37 17-18-46 10-14-29 27-25-54 0-0-0 3-3-4

Lead After Three Innings

  • Here are their records after the first three innings in 2026.
    Total Home Road Favorite Underdog Neutral Last 10
    Guardians 58-52-49 35-25-21 23-27-28 39-33-28 19-19-21 0-0-0 6-1-3
    Royals 50-71-38 29-32-17 21-39-21 15-25-13 35-46-25 0-0-0 2-6-2

NRFI/YRFI

The NRFI market is paying -125 and the YRFI is paying -105.

  • The NRFI is 90-69 in Guardians games this season. The Royals have a 77-82 NRFI record.

Last Time They Met

The Guardians recorded a lopsided 11-1 victory against the Royals at Progressive Field when these teams last met on August 30. Jose Ramirez was unstoppable in that matchup, hitting a home run, a single and recording 4 RBIs.