MLB Prop Bets: Arizona Diamondbacks vs Chicago White Sox (April 21, 2026)
The Chicago White Sox (8-14) face the Arizona Diamondbacks (13-9) at Chase Field on Tuesday at 9:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Sean Burke is the probable pitcher for the White Sox, while Merrill Kelly is the probable pitcher for the Diamondbacks. The Diamondbacks are favored to win at -156, while the White Sox are at +129. The total runs line is set at 9.0, with OVER at -105 and UNDER at -115.
- The White Sox (-156) have a 10-12 Run Line record this season, while the Diamondbacks (+129) hold a record of 16-6.
- The White Sox have a 14-8-0 O/U record this season (meaning 14 games have gone over the total runs line and eight have gone under). The Diamondbacks have a 12-8-2 O/U record.
Scoring Insights
- The White Sox are averaging 3.7 runs per game this season (25th in the league). Comparatively, the Diamondbacks are averaging +0.8 more at 4.5 runs (14th).
- In the field, the White Sox are allowing a whopping 5.1 runs per game this season (25th in the league), while the Diamondbacks are allowing an average of 4.6 runs (T19th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the White Sox are at .210 (ranking 29th in the Major leagues), while the Diamondbacks are batting .242 (13th).
Home Runs
- In terms of total home runs this season, the Diamondbacks have hit 18 (T22nd in the Major Leagues). Meanwhile, the White Sox have managed 24 (T12th).
Runs Batted In
- Finally, looking at their runs batted in, the White Sox have recorded 74 RBIs to rank 27th in the MLB this season. Comparatively, the Diamondbacks have recorded 94 RBIs to rank 17th.
Pitching Insights:
Earned Run Average
- The Diamondbacks have an earned run average of 4.01 this season (13th in the Majors), while The White Sox have an ERA of 4.83 (26th).
Strikeouts
- Turning our attention to total strikeouts, the White Sox have recorded 169 this season, ranking 28th in the MLB. Meanwhile, the Diamondbacks rank 29th for total strikeouts, recording 162.
Opponent Batting Average
- Opponents are batting an average of .242 against the Diamondbacks this season (19th in the Major Leagues). Comparatively, the White Sox's opponents are at .243 (20th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 7-4-11 | 3-1-5 | 4-3-6 | 0-0-0 | 7-4-11 | 0-0-0 | 2-2-6 |
| Diamondbacks | 6-5-11 | 2-2-6 | 4-3-5 | 1-0-3 | 5-5-8 | 0-0-0 | 2-3-5 |
Lead After Three Innings
The White Sox are +110 to lead after three innings, while the Diamondbacks are -140.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| White Sox | 11-7-4 | 5-2-2 | 6-5-2 | 0-0-0 | 11-7-4 | 0-0-0 | 4-4-2 |
| Diamondbacks | 7-9-6 | 3-3-4 | 4-6-2 | 2-0-2 | 5-9-4 | 0-0-0 | 2-5-3 |
NRFI/YRFI
The NRFI market is paying -110 and the YRFI is paying -120.
- The NRFI is 11-11 in White Sox games this season. The Diamondbacks have a 9-13 NRFI record.
Last Time They Met
The White Sox recorded a 7-3 victory over the Diamondbacks at Rate Field when these teams last met on June 25, 2025. Lenyn Sosa was crushing the ball in that matchup, hitting 2 home runs and recording 4 RBIs. That result snapped the Diamondbacks' three-game winning streak against the White Sox.
