MLB Prop Bets: Miami Marlins vs St. Louis Cardinals (April 21, 2026)
The St. Louis Cardinals (13-9) face the Miami Marlins (11-12) at LoanDepot Park on Tuesday at 6:40pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Dustin May is the probable pitcher for the Cardinals, while Chris Paddack is the probable pitcher for the Marlins. The Cardinals opened as favorites but this has since changed, with the Marlins coming into -120 and Cardinals drifting to +100. The total runs line is set at 8.5, with OVER at -115 and UNDER at -105.
- The Cardinals (+154) have a 13-9 Run Line record this season, while the Marlins (-188) hold a record of 9-14.
- The Cardinals have a 13-9-0 O/U record this season (meaning 13 games have gone over the total runs line and nine have gone under). The Marlins have a 14-7-2 O/U record.
Scoring Insights
- The Cardinals are averaging 4.8 runs per game this season (11th in the league). Comparatively, the Marlins are averaging 4.6 (13th).
- In the field, the Cardinals are allowing a whopping 5.3 runs per game this season (27th in the league), while the Marlins are allowing an average of 4.5 runs (16th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Cardinals are at .230 (ranking 20th in the Major leagues), while the Marlins are batting .254 (5th).
Home Runs
- In terms of total home runs this season, the Marlins have hit 16 (T27th in the Major Leagues). Meanwhile, the Cardinals have managed 25 (T8th).
Runs Batted In
- Finally, looking at their runs batted in, the Cardinals have recorded 103 RBIs to rank T9th in the MLB this season. Comparatively, the Marlins have recorded 100 RBIs to rank 12th.
Pitching Insights:
Earned Run Average
- The Marlins have an earned run average of 4.01 this season (14th in the Majors), while The Cardinals have an ERA of 4.86 (27th).
Strikeouts
- Turning our attention to total strikeouts, the Cardinals have recorded 140 this season, ranking 30th in the MLB. Meanwhile, the Marlins rank 9th for total strikeouts, recording 203.
Opponent Batting Average
- Opponents are batting an average of only .216 against the Marlins this season (3rd in the Major Leagues). Alternatively, the Cardinals' opponents are at .253 (26th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 4-4-14 | 1-2-9 | 3-2-5 | 0-2-1 | 4-2-13 | 0-0-0 | 2-2-6 |
| Marlins | 5-5-13 | 3-1-10 | 2-4-3 | 3-1-10 | 2-4-3 | 0-0-0 | 2-2-6 |
Lead After Three Innings
The Cardinals are -110 to lead after three innings, while the Marlins are -120.
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Cardinals | 7-6-9 | 4-2-6 | 3-4-3 | 1-1-1 | 6-5-8 | 0-0-0 | 3-2-5 |
| Marlins | 8-9-6 | 6-3-5 | 2-6-1 | 6-3-5 | 2-6-1 | 0-0-0 | 3-4-3 |
NRFI/YRFI
The NRFI market is paying -120 and the YRFI is paying -110.
- The NRFI is 11-11 in Cardinals games this season. The Marlins have a 12-11 NRFI record.
Last Time They Met
The Marlins recorded a 5-3 victory over the Cardinals at LoanDepot Park yesterday. Despite being on the wrong side of that result, Masyn Winn did what he could, hitting a home run.
