MLB Prop Bets: Cleveland Guardians vs Houston Astros (April 21, 2026)
The Houston Astros (9-15) face the Cleveland Guardians (13-11) at Progressive Field on Tuesday at 6:10pm (ET). Let's take a look at the MLB Prop Bets for the matchup. Ryan Weiss is the probable pitcher for the Astros, while Parker Messick is the probable pitcher for the Guardians. The Guardians are favored to win at -149, while the Astros are at +123. The total runs line is set at 8.0, with OVER at -118 and UNDER at -102.
- The Astros (-171) have a 9-15 Run Line record this season, while the Guardians (+141) hold a record of 13-11.
- The Astros have a 17-7-0 O/U record this season (meaning 17 games have gone over the total runs line and seven have gone under). The Guardians have a 12-12-0 O/U record.
Scoring Insights
- The Astros are averaging 5.4 runs per game this season (4th in the league). Comparatively, the Guardians are averaging only 4.0 (21st).
- In the field, the Astros are allowing a whopping 5.9 runs per game this season (29th in the league), while the Guardians are allowing an average of 4.3 runs (12th).
Let's take a look at how these teams perform in some other key statistical areas.
Batting Insights:
Batting Average
- Looking at their batting averages this season, the Astros are at .260 (ranking 3rd in the Major leagues), while the Guardians are batting .227 (21st).
Home Runs
- In terms of total home runs this season, the Guardians have hit 25 (T8th in the Major Leagues). Meanwhile, the Astros have managed 30 (T4th).
Runs Batted In
- Finally, looking at their runs batted in, the Astros have recorded 122 RBIs to rank 3rd in the MLB this season. Comparatively, the Guardians have recorded 92 RBIs to rank 18th.
Pitching Insights:
Earned Run Average
- The Guardians have an earned run average of 4.09 this season (18th in the Majors), while The Astros have an ERA of 5.93 (30th).
Strikeouts
- Turning our attention to total strikeouts, the Astros have recorded 228 this season, ranking 2nd in the MLB. Meanwhile, the Guardians rank 1st for total strikeouts, recording 233.
Opponent Batting Average
- Opponents are batting an average of .228 against the Guardians this season (9th in the Major Leagues). Comparatively, the Astros' opponents are at .262 (27th).
First Innings Moneyline
- Here are their first innings moneyline records in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Astros | 8-8-8 | 5-3-5 | 3-5-3 | 4-4-8 | 4-4-0 | 0-0-0 | 3-6-1 |
| Guardians | 5-1-18 | 2-1-8 | 3-0-10 | 1-1-7 | 4-0-11 | 0-0-0 | 3-1-6 |
Lead After Three Innings
- Here are their records after the first three innings in 2026.
| Total | Home | Road | Favorite | Underdog | Neutral | Last 10 | |
|---|---|---|---|---|---|---|---|
| Astros | 9-8-7 | 6-4-3 | 3-4-4 | 6-6-4 | 3-2-3 | 0-0-0 | 5-4-1 |
| Guardians | 8-7-9 | 4-3-4 | 4-4-5 | 3-1-5 | 5-6-4 | 0-0-0 | 3-1-6 |
NRFI/YRFI
The NRFI market is paying -130 and the YRFI is paying +100.
- The NRFI is 7-17 in Astros games this season. The Guardians have a 15-9 NRFI record.
Last Time They Met
The Astros recorded a 9-2 victory over the Guardians at Progressive Field yesterday. Isaac Paredes was crushing the ball in that matchup, hitting 2 home runs and recording 2 RBIs. That result snapped the Guardians' four-game winning streak against the Astros.
